Blesa, J., Trigo-Damas, I., Quiroga-Varela, A. & Jackson-Lewis, V. R. Oxidative stress and Parkinson’s illness. Entrance Neuroanat 9, 91 (2015).
Wang, X. & Michaelis, E. Okay. Selective neuronal vulnerability to oxidative stress within the mind. Entrance Growing old Neurosci 2, 12 (2010).
Ghouili, I. et al. Endogenous expression of ODN-related peptides in astrocytes contributes to cell safety in opposition to oxidative stress: astrocyte-neuron crosstalk relevance for neuronal survival. Mol. Neurobiol 55, 4596–4611 (2017).
Dennery, P. A. Oxidative stress in growth: nature or nurture? Free Radic Biol Med 49, 1147–1151 (2010).
Block, M. L., Zecca, L. & Hong, J. S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci Eight, 57–69 (2007).
Zhou, D., Shao, L. & Spitz, D. R. Reactive oxygen species in regular and tumor stem cells. Adv Most cancers Res 122, 1–67 (2014).
Pei, D. S. & Strauss, P. R. Zebrafish as a mannequin system to review DNA injury and restore. Mutat Res 743
744, 151−159 (2013).
Lu, C. J. et al. Graphene oxide nanosheets induce DNA injury and activate the bottom excision restore (BER) signaling pathway each in vitro and in vivo. Chemosphere 184, 795–805 (2017).
Seeberg, E., Eide, L. & Bjoras, M. The bottom excision restore pathway. Traits Biochem Sci 20, 391–397 (1995).
Fromme, J. C. & Verdine, G. L. Base excision restore. Adv Protein Chem 69, 1–41 (2004).
Xanthoudakis, S., Smeyne, R. J., Wallace, J. D. & Curran, T. The redox/DNA restore protein, Ref-1, is important for early embryonic growth in mice. Proc Natl Acad Sci U S A 93, 8919–8923 (1996).
Tebbs, R. S. et al. Requirement for the Xrcc1 DNA base excision restore gene throughout early mouse growth. Dev Biol 208, 513–529 (1999).
Larsen, E., Gran, C., Saether, B. E., Seeberg, E. & Klungland, A. Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice on the blastocyst stage. Mol Cell Biol 23, 5346–5353 (2003).
Sugo, N., Aratani, Y., Nagashima, Y., Kubota, Y. & Koyama, H. Neonatal lethality with irregular neurogenesis in mice poor in DNA polymerase beta. EMBO J 19, 1397–1404 (2000).
Wu, D. et al. Uracil-DNA glycosylase is concerned in DNA demethylation and required for embryonic growth within the zebrafish embryo. J Biol Chem 289, 15463–15473 (2014).
Wang, Y., Shupenko, C. C., Melo, L. F. & Strauss, P. R. DNA restore protein concerned in coronary heart and blood growth. Mol Cell Biol 26, 9083–9093 (2006).
Yan, L. et al. Eight-Oxoguanine DNA glycosylase 1 (ogg1) maintains the operate of cardiac progenitor cells throughout coronary heart formation in zebrafish. Exp Cell Res 319, 2954–2963 (2013).
Pei, D. S. et al. A novel regulatory circuit in base excision restore involving AP endonuclease 1, Creb1 and DNA polymerase beta. Nucleic Acids Res 39, 3156–3165 (2011).
Moore, S. P., Toomire, Okay. J. & Strauss, P. R. DNA modifications repaired by base excision restore are epigenetic. DNA Restore (Amst) 12, 1152–1158 (2013).
Moore, S. P., Kruchten, J., Toomire, Okay. J. & Strauss, P. R. Transcription components and DNA restore enzymes compete for broken promoter websites. J Biol Chem 291, 5452–5460 (2016).
Carlezon, W. A. Jr., Duman, R. S. & Nestler, E. J. The numerous faces of CREB. Traits Neurosci 28, 436–445 (2005).
Silva, A. J., Kogan, J. H., Frankland, P. W. & Kida, S. CREB and reminiscence. Annu Rev Neurosci 21, 127–148 (1998).
Zhou, Y. et al. CREB regulates excitability and the allocation of reminiscence to subsets of neurons within the amygdala. Nat Neurosci 12, 1438–1443 (2009).
Han, J. H. et al. Neuronal competitors and choice throughout reminiscence formation. Science 316, 457–460 (2007).
Mantamadiotis, T. et al. Disruption of CREB operate in mind results in neurodegeneration. Nat Genet 31, 47–54 (2002).
Tsui, D. et al. CBP regulates the differentiation of interneurons from ventral forebrain neural precursors throughout murine growth. Dev Biol 385, 230–241 (2014).
Dworkin, S. et al. CREB exercise modulates neural cell proliferation, midbrain-hindbrain group and patterning in zebrafish. Dev Biol 307, 127–141 (2007).
Mohammed, M. Z. et al. Improvement and analysis of human AP endonuclease inhibitors in melanoma and glioma cell strains. Br J Most cancers 104, 653–663 (2011).
Chen, Y., Li, J. & Mo, Z. Affiliation between the APEX1 Asp148Glu polymorphism and prostate most cancers, particularly amongst Asians: a brand new evidence-based evaluation. Oncotarget. https://doi.org/10.18632/oncotarget.9693 (2016).
Mahjabeen, I., Baig, R. M., Sabir, M. & Kayani, M. A. Genetic and expressional variations of APEX1 are related to elevated danger of head and neck most cancers. Mutagenesis 28, 213–218 (2013).
Jiang, S. et al. Ape1 regulates WNT/beta-catenin signaling by way of its redox purposeful area in pancreatic most cancers cells. Int J Oncol 47, 610–620 (2015).
Kim, M. H. etal. Colon most cancers development is pushed by APEX1-mediated upregulation of Jagged. J Clin Make investments 123, 3211–3230 (2013).
Antoniali, G. et al. Mammalian APE1 controls miRNA processing and its interactome is linked to most cancers RNA metabolism. Nat Commun Eight, 797 (2017).
Thakur, S. et al. APE1/Ref-1 as an rising therapeutic goal for numerous human illnesses: phytochemical modulation of its features. Exp Mol Med 46, e106 (2014).
Xanthoudakis, S., Miao, G., Wang, F., Pan, Y. C. & Curran, T. Redox activation of Fos-Jun DNA binding exercise is mediated by a DNA restore enzyme. EMBO J 11, 3323–3335 (1992).
Busso, C. S., Iwakuma, T. & Izumi, T. Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway. Oncogene 28, 1616–1625 (2009).
Gaiddon, C., Moorthy, N. C. & Prives, C. Ref-1 regulates the transactivation and pro-apoptotic features of p53 in vivo. EMBO J 18, 5609–5621 (1999).
Logsdon, D. P. et al. Regulation of HIF1alpha below hypoxia by APE1/Ref-1 impacts CA9 expression: dual-targeting in patient-derived 3D pancreatic most cancers fashions. Mol. Most cancers Ther 15, 2722–2732 (2016).
Raffoul, J. J., Heydari, A. R. & Hillman, G. G. DNA restore and most cancers remedy: concentrating on APE1/Ref-1 utilizing dietary brokers. J Oncol 2012, 370481 (2012).
Mantamadiotis, T. et al. Disruption of CREB operate in mind results in neurodegeneration. Nature Genetics 31, 47 (2002).
Yang, J. L., Lin, Y. T., Chuang, P. C., Bohr, V. A. & Mattson, M. P. BDNF and train improve neuronal DNA restore by stimulating CREB-mediated manufacturing of apurinic/apyrimidinic endonuclease 1. Neuromol Med 16, 161–174 (2014).
Branzei, D. & Foiani, M. Regulation of DNA restore all through the cell cycle. Nat Rev Mol Cell Biol 9, 297–308 (2008).
Stuart, J. A. et al. DNA base excision restore actions and pathway operate in mitochondrial and mobile lysates from cells missing mitochondrial DNA. Nucleic Acids Res 32, 2181–2192 (2004).
Haghdoost, S., Czene, S., Naslund, I., Skog, S. & Harms-Ringdahl, M. Extracellular Eight-oxo-dG as a delicate parameter for oxidative stress in vivo and in vitro. Free Radic Res 39, 153–162 (2005).
Chang, J. T., Lehtinen, M. Okay. & Sive, H. Zebrafish cerebrospinal fluid mediates cell survival by way of a retinoid signaling pathway. Dev Neurobiol
Gutzman, J. H. & Sive, H. Zebrafish mind ventricle injection. J Vis Exp 26, 1218 (2009).
Mikkola, I. et al. The paired domain-containing nuclear issue pax[b] is expressed in particular commissural interneurons in zebrafish embryos. J Neurobiol 23, 933–946 (1992).
Bourdon, J. C. et al. p53 isoforms can regulate p53 transcriptional exercise. Genes Dev 19, 2122–2137 (2005).
Robu, M. E. et al. p53 activation by knockdown applied sciences. PLoS Genet three, e78 (2007).
Gerety, S. S. & Wilkinson, D. G. Morpholino artifacts present pitfalls and reveal a novel position for pro-apoptotic genes in hindbrain boundary growth. Dev Biol 350, 279–289 (2011).
Berghmans, S. et al. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A 102, 407–412 (2005).
Inform, G., Quadrifoglio, F., Tiribelli, C. & Kelley, M. R. The numerous features of APE1/Ref-1: not solely a DNA restore enzyme. Antioxid Redox Sign 11, 601–620 (2009).
Zaky, A. et al. Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA injury. Nucleic Acids Res 36, 1555–1566 (2008).
Beckerman, R. & Prives, C. Transcriptional regulation by p53. Chilly Spring Harb Perspect Biol 2, a000935 (2010).
Deshmukh, M., Kuida, Okay. & Johnson, E. M. Jr. Caspase inhibition extends the dedication to neuronal loss of life past cytochrome c launch to the purpose of mitochondrial depolarization. J Cell Biol 150, 131–143 (2000).
Kirkland, R. A. & Franklin, J. L. Proof for redox regulation of cytochrome C launch throughout programmed neuronal loss of life: antioxidant results of protein synthesis and caspase inhibition. J Neurosci 21, 1949–1963 (2001).
Liu, D. et al. Proof that OGG1 glycosylase protects neurons in opposition to oxidative DNA injury and cell loss of life below ischemic situations. J Cereb Blood Stream Metab 31, 680–692 (2011).
Radak, Z. & Boldogh, I. Eight-Oxo-7,Eight-dihydroguanine: hyperlinks to gene expression, getting old, and protection in opposition to oxidative stress. Free Radic Biol Med 49, 587–596 (2010).
Lowery, L. A. & Sive, H. Completely tubular: the thriller behind operate and origin of the mind ventricular system. Bioessays 31, 446–458 (2009).
Georgiadis, M. M. et al. Evolution of the redox operate in mammalian apurinic/apyrimidinic endonuclease. Mutation Res/Fundament Mol Mech Mutagen 643, 54–63 (2008).
Ordway, J. M., Eberhart, D. & Curran, T. Cysteine 64 of Ref-1 just isn’t important for redox regulation of AP-1 DNA binding. Mol Cell Biol 23, 4257–4266 (2003).
Sakamoto, Okay., Karelina, Okay. & Obrietan, Okay. CREB: a multifaceted regulator of neuronal plasticity and safety. J Neurochem 116, 1–9 (2011).
Stetler, R. A. et al. Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection in opposition to world cerebral ischemia. Proc Natl Acad Sci U S A 107, 3204–3209 (2010).
Huang, E. et al. The position of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal loss of life. Nat Cell Biol 12, 563–571 (2010).
Kwiatkowski, D. et al. Affiliation between single-nucleotide polymorphisms of the hOGG1,NEIL1,APEX1, FEN1,LIG1, and LIG3 genes and Alzheimer’s illness danger. Neuropsychobiology 73, 98–107 (2016).
Thakur, S., Dhiman, M., Inform, G. & Mantha, A. Okay. A assessment on protein-protein interplay community of APE1/Ref-1 and its related organic features. Cell Biochem Funct 33, 101–112 (2015).
Fortier, S., Yang, X., Wang, Y., Bennett, R. A. & Strauss, P. R. Base excision restore in early zebrafish growth: proof for DNA polymerase switching and standby AP endonuclease exercise. Biochemistry 48, 5396–5404 (2009).
Ravanat, J. L., Di Mascio, P., Martinez, G. R. & Medeiros, M. H. Singlet oxygen induces oxidation of mobile DNA. J Biol Chem 276, 40601–40604 (2001).
Pei, D. S. et al. Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos. BMC Dev Biol Eight, 29 (2008).
Macdonald, R. in Molecular Strategies in Developmental Biology: Xenopus and Zebrafish (ed Guille, M., Humana Press, New York) 77–88 (1999).